LCMS (Liquid Chromatography–Mass Spectrometry)

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This overview covers the fundamentals of Liquid Chromatography-Mass Spectrometry (LCMS), emphasizing the integration of separation techniques with molecular detection. It outlines the workflow for sample preparation, ionization optimization, and the interpretation of chromatograms and mass spectra, illustrated by a case study on drug quantification in plasma. Additionally, it highlights the importance of validating results for accuracy and precision, and the strategic use of targeted versus...