Evaluating Mucoactive Agents in Acute Respiratory Failure: MARCH Trial Findings

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In this lecture, we delve into the MARCH Trial, a pivotal phase 3 study assessing mucoactive agents in respiratory failure. Although commonly used, these agents show limited efficacy and raise safety concerns. The trial involved 1956 ventilated participants, evaluating interventions like carbocisteine and hypertonic saline against control groups. Results highlighted no significant reduction in ventilation duration and potential risks such as bleeding and airway constriction. Consequently,...