Create a professional 12-minute Master's Thesis Defense presentation based exclusively on my uploaded thesis. The goal is to clearly communicate the scientific rationale, research question and hypothesis, systematic review methodology, study characteristics, risk of bias, meta-analysis methodology, main quantitative results, interpretation, limitations, and future perspectives. This is a European biomedical Master's thesis defense, not a business presentation. The presentation should tell a clear scientific story from the clinical problem to the research question, methods, main findings, critical interpretation, and conclusion. The uploaded thesis is the authoritative source. Preserve its terminology, scientific interpretation, numerical results, statistical values, figures, and conclusions exactly. Do not invent or replace scientific information.