Dual-Antigen Membranous Nephropathy: Diagnostic Advances and Insights

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This lecture introduces dual-antigen membranous nephropathy (MN), a condition characterized by nephrotic syndrome in adults due to immune complex formation by autoantibodies. The study aims to identify cases utilizing advanced techniques like LC MS/MS and microscopy to enhance diagnostic accuracy. Methods used include laser microdissection and antigen analysis, confirming 9 cases with a 2.6% prevalence in some MN subtypes. Findings highlight podocyte-related antigens like NELL1 and CNTN1....