Microbial Genomes – Investigating an Outbreak Several patients in a hospital develop infections caused by bacteria that appear resistant to multiple antibiotics. As a molecular microbiology team, evaluate how mutations, plasmids, and horizontal gene transfer could have contributed to the emergence and spread of resistance. Propose genetic methods that could be used to investigate whether the isolates are related.
Microbial Genomes – Investigating an Outbreak Several patients in a hospital develop infections caused by bacteria that appear resistant to multiple antibiotics. As a molecular microbiology team, evaluate how mutations, plasmids, and horizontal gene transfer could have contributed to the emergence and spread of resistance. Propose genetic methods that could be used to investigate whether the isolates are related.
Created using ChatSlide
This guide outlines a systematic approach to understanding outbreaks and resistance in pathogens. It begins by defining the outbreak and mapping resistance patterns, followed by tracing genetic drivers and transmission routes through advanced genomic techniques. Finally, it emphasizes confirming relatedness using whole genome sequencing and phylogenetics to build transmission networks, ultimately recommending effective containment and infection control strategies.