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This project focuses on targeting the b17 nAChR for treating Major Depressive Disorder (MDD), which affects 300 million people globally. It highlights the challenges of delivering therapies across the blood-brain barrier and proposes a targeted siRNA platform utilizing RMT for effective cargo delivery. The design incorporates PDCD4 silencing to enhance BDNF levels in the hippocampus, guided by RVG and b1-bungarotoxin. The project aims to validate this approach through molecular design and...