Selective Microglial Activation Effects on Feeding Behaviour 🧠

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This study investigates how hypothalamic microglia regulate feeding behaviour and metabolic homeostasis through glucose-stimulated GDNF dynamics. The central hypothesis explores the role of glucose as a stimulus driving GDNF signalling in neural circuits. Research objectives include understanding GDNF synthesis mechanisms, evaluating its functional necessity for metabolic regulation, and examining microglial activation in feeding suppression. Findings aim to offer insights into neural-...