PAPA Syndrome - neutrophillic dermatosis. I am presenting at rheumatology/dermatology clinic so i want to highlight the important overlap

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This lecture on PAPA Syndrome provides a comprehensive overview of this autoinflammatory disorder driven by IL-1. It covers its genetic basis, focusing on the PSTPIP1 gene mutation with autosomal dominant inheritance and classic symptom triad. Rheumatologic features include sterile pyogenic arthritis and laboratory findings, while dermatologic aspects discuss pyoderma gangrenosum, severe cystic acne, and diagnostic tips. The diagnostic approach emphasizes recurrent sterile arthritis and the...