SIRT3 Activation in PND Neuroprotection

This lecture will delve into post-surgery neurological conditions (PND) and ferroptosis mechanisms, with a focus on the neuroprotective role of SIRT3. Research objectives aim to explore how SIRT3 modulation by Honokiol impacts cognitive decline and cell damage in a mouse PND model. Methods include behavioral assays, molecular studies, and genetic insights. Key findings reveal Honokiol's activation of SIRT3, influencing GPX4 regulation to inhibit ferroptosis. The application of SIRT3-targeted...