Paneth Cells: Guardians of Intestinal Immunity
Paneth Cells: Guardians of Intestinal Immunity
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Delve into the specialised roles of cellular components within the small intestine, focusing on Paneth, M, and Goblet cells. Understand the strategic positioning of Paneth cells at the crypt base, their limited number, and their crucial role in innate immunity through antimicrobial peptide (AMP) secretion, critical for preventing microbial invasion, and their implications in diseases like Crohn's. Explore the microbe recognition of Paneth cells via TLRs and NOD2. Examine M cells' role in...