Please create a poster (size: 1.0 m horizontal × 0.95 m vertical with diagrams for the following Abstract to be presented at 2026 Annual research meeting of noguchi Memeorial Institutrte of medical research in Accra; Title of Abstract: Targeting the Warburg Effect: Exploiting Glycolytic Vulnerabilities and Phosphomannose Isomerase Activity in Cancer Therapeutics. A Promising Paradigm for Cancer Therapeutics
Please create a poster (size: 1.0 m horizontal × 0.95 m vertical with diagrams for the following Abstract to be presented at 2026 Annual research meeting of noguchi Memeorial Institutrte of medical research in Accra; Title of Abstract: Targeting the Warburg Effect: Exploiting Glycolytic Vulnerabilities and Phosphomannose Isomerase Activity in Cancer Therapeutics. A Promising Paradigm for Cancer Therapeutics
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This project explores metabolic vulnerabilities in cancer, focusing on the Warburg Effect and its implications for treatment. It discusses a dual nutritional strategy involving mannose and its conversion to M6P, highlighting the toxic accumulation due to low PMI. An integrated model is proposed, combining mannose, fructose, and medium-chain fatty acids to reduce tumor glycolysis and enhance T cell function, offering a promising outlook for cancer interventions.