Mutation Frequency in Large vs. Small Clones

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Explore whether larger clones exhibit more mutations by focusing on VH4-34+ memory B cells. The study integrates V and IgH gene sequencing to identify clones at the single-cell level. In research, flow sorting is used to isolate VH4-34+ B cells, followed by single-cell expansion and whole-exome sequencing to analyze the mutations. Selection criteria involve comparing large and small clones based on their frequency and mutation quantities, utilizing comprehensive sequencing data. This research...