Pharmacophore Modeling in Drug Discovery 🧬

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This project from QAU, Islamabad, focuses on pharmacophore modeling for T2DM treatment, targeting DPP-4, SGLT2, PTP1B, and GK proteins. It analyzes methodologies from five research articles, summarizing strategies and validation metrics with an emphasis on a dual-pharmacophore approach. The challenges in drug discovery and the features of LigandScout software are discussed, along with specific insights into each target protein. Both ligand-based and dynamic receptor-based models are explored,...