Provide bases for a research group presentation
Provide bases for a research group presentation
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Explore the molecular choreography of synaptic vesicle fusion: SNARE proteins generate fusion energy, while Munc18-1 and Munc13 license docking and assembly. Follow trans-SNARE zippering, complexin-mediated priming, and calcium sensing by synaptotagmin-1 within nanodomains to trigger pore opening. Conclude with cis-SNARE recycling, as α-SNAP and NSF use ATP to disassemble the post-fusion complex and reset the machinery.