Red-Shifted Protein Labelling with Minimalist Aromatic Cations

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This research explores visible-light PET protein labeling through red-shifted pyridinium salts, addressing photochemical labeling challenges. It focuses on designing conjugation-extended pyridinium salts while optimizing donor-acceptor dynamics for biocompatibility. Experimental results showcase efficient protein labeling, synthesis of novel probes, and live-cell imaging applications. The study concludes with the development of advanced pyridinium probes, underscoring their potential in...