CTCF Disruption and DPP6 Regulation in IDH-Mutant Gliomas

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This presentation explores the research focus on IDH-mutant gliomas, emphasizing the impact of IDH mutations and CTCF disruption on the SHH locus. It outlines key findings from qPCR and single-cell transcriptomics, methodologies like HiC analysis and gene probing, and challenges such as minimal gene expression and methylation roles. Current progress includes developing cell lines and editing techniques like Cas9. Future directions focus on expanding studies on DPP6 and its therapeutic...