Immunosurveillance Failure in OSCC: Genetic and Epigenetic Insights

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This lecture provides an in-depth exploration of the immunological and genetic factors contributing to oral squamous cell carcinoma (OSCC). It begins with an overview of immunosurveillance, highlighting its role in cancer defence. The lecture then delves into the genetic mutations and epigenetic alterations, including DNA methylation and miRNA dysregulation, that abet OSCC development. Furthermore, it examines how OSCC evades immune detection through checkpoint upregulation and immune cell...