Epigenetic Disruptions in IDH-Mutant Gliomas and Therapeutic Insights

This presentation explores the significance of IDH-mutant gliomas by examining epigenetic lesions, including DNA hypermethylation and disrupted insulators. Utilizing advanced methodologies such as Hi-C, CRISPR-based epigenetic editing, and genome topology analysis, the study identifies critical findings like the effects on SHH expression, DPP6 involvement, and responses to decitabine treatment. It concludes by emphasizing the role of epigenetic disruptions, potential therapeutic targets, and...