Understanding Off-Target Effects in Anti-Myostatin Therapies

Created using ChatSlide

This review explores the mechanistic basis of myostatin blockade for muscle growth, highlighting shared ActRII receptors and the limitations of current methods. It addresses clinical and preclinical off-target effects, including bleeding and reproductive concerns linked to ActRII traps. The specificity of myostatin-specific antibodies is discussed, alongside a mechanism-to-effect map of therapies and identified evidence gaps. The review concludes with recommendations for next-generation...