Challenges in CNS Infection Therapy: Drug Penetration

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This presentation delves into the complexities of treating CNS infections, emphasizing therapeutic challenges posed by drug-resistant pathogens and the pharmacokinetics of CNS-targeted medications. Key topics include the physiology and barriers of the CNS, drug exchange mechanisms, and compartmental dynamics. Techniques to study CNS drug penetration, limitations of current methods, and the pivotal role of CSF sampling will be explored. The focus extends to the properties of anti-infective...