Targeting CCL20 for Pulmonary Fibrosis Treatment
Targeting CCL20 for Pulmonary Fibrosis Treatment
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This lecture outlines a comprehensive exploration of pulmonary fibrosis (PF), emphasizing the limited treatment effectiveness and crucial fibroblast activation. We'll delve into the elevated CCL20 in PF models and patients, highlighting AEC2 cells as a source and its interaction with integrin α5β1. This interaction heightens TGF-β signaling, promoting fibroblast differentiation and worsening fibrosis. Therapeutic strategies targeting CCL20-integrin interaction, such as AEC2 CCL20 deletion,...