Innovative Anterograde Tracing with ATLAS Technology

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The ATLAS design and validation project explores existing tracers' limitations and the innovative AMPA.FingR design for vesicle release. It highlights initial culture and in vivo tracing results, focusing on genetically targeted circuit labelling and evidence for monosynaptic transfer. The study assesses efficiency, electrophysiology, and potential toxicity. Future applications include ATLASsn pathways in mice and validation in rats, discussing advantages and limitations while proposing a...