Slide 1 — Title and key message Time: 30 seconds Title: The 150-day clinical trial set-up target: implications for research delivery teams Open with: “The 150-day target is designed to move clinical trials from regulatory submission to recruiting the first participant more quickly, while maintaining quality, safety and regulatory compliance.” Slide 2 — What is the 150-day target? Time: 1 minute Show the timeline visually: Regulatory submission → Approval → Site opening → First participant recruited 60 days: combined regulatory review. 60 days: approval to site opening. 30 days: site opening to first participant recruited. Total: 150 days. Key point: Successful set-up does not end when approvals are received. It ends when the study is operational and has recruited its first participant. Slide 3 — Why does it matter? Time: 1 minute Cover the main reasons: Earlier access to research for patients. Greater predictability for sponsors and funders. Improved UK competitiveness for commercial research. Less duplication and unnecessary delay. Better use of NHS research capacity and resources. Key message: The target creates shared accountability across regulators, sponsors, R&D teams, investigators and research delivery teams.