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This presentation will delve into the evolution of response-guided radiotherapy (RT) with a key focus on HPV-positive cancers. It will explore the rationale for de-escalation strategies, highlighting approaches that aim to lessen long-term toxicities while preserving treatment efficacy through advanced imaging and biomarkers. Insights from pivotal clinical trials, such as OPTIMA and PATHOS, will be discussed, showcasing significant progress in toxicity reduction. Challenges, including...