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This case highlights the importance of recognizing atypical presentations in a 49-year-old man with recurrent melena and severe anemia, despite no alarming abdominal findings. Initial differential diagnoses include PNET and PDAC, with GIST considered among rare periampullary lesions. Management involves resuscitation with PRBCs. Histological confirmation reveals a low-grade pancreatic-head GIST, measuring 3.5 cm with low mitotic activity, and a positive immunophenotype for CD117, CD34, and...