Role of Torsin1A in Nuclear Envelope Function

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This study explores the role of Torsin1A in nuclear envelope function, particularly its relationship with CLCC1 in membrane fusion during nuclear pore complex (NPC) biogenesis. It highlights how Torsin1A sustains CLCC1-mediated membrane fusion, supported by cellular and molecular evidence. The implications of defective NPC biogenesis on nuclear function and the connection between Torsin1A dysfunction and dystonia are discussed, emphasizing the study's significance and potential future...