The role of esophageal gland in host immune evasion by Schistosoma mansoni

This research explores the critical role of the esophageal gland in Schistosoma mansoni, focusing on stem cell-driven development and immune evasion mechanisms. Formation of the gland is essential for parasite survival, with Sm-foxA knockdown impairing gland formation and restricting survival to immunocompromised hosts. The gland facilitates immune cell lysis and prevents their entry into the parasite gut, showcasing its importance in host immune evasion. Targeting gland development presents...