HBV Assembly: Role of Large Envelope Protein

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This study explores HBV assembly, focusing on the structure and roles of large hepatitis B surface proteins (LHBs) in virion formation. It details an experimental strategy using Huh-7 cells to map core-LHB interactions through FLIM-FRET and TEM techniques. Key findings reveal that LHBs facilitate capsid recruitment to membrane-rich domains, with late endosome markers co-localizing, highlighting the necessity of matrix domains and preassembled capsids in the assembly process.