thesis for phd defense frei university

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This overview explores the intricate roles of chromatin and RNA-DNA hybrids in genomic stability and transcription regulation. Chromatin structures influence DNA packaging and transcription, while RNA-DNA hybrids adopt unique helical forms that facilitate protein interactions. Transient hybrids support normal DNA metabolism, and R-loops create three-stranded platforms that regulate genomic functions. The formation and resolution of R-loops are driven by topology and sequence, with...