Create a presentation to share the findings of this paper to scientific colleagues. Include the methodology, relevant figures from the paper and a summary. Make it easy to understand.

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This study aims to map spatial tissue signatures in MDS, addressing the challenge of localising disease activity. By profiling marrow structure across various disease states and integrating imaging with spatial molecular analysis, we define cellular niches and tissue regions. The findings suggest that remodelling of tissue architecture distinguishes different disease activity states, with significant biological and clinical implications.