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This presentation delves into the KEAP1/NRF2 pathway, highlighting its dual role in NRF2 activation and inhibition. While NRF2 activation is explored with a focus on neurodegenerative diseases, inhibition targets cancer resistance. Confidence in the rationale and safety for both strategies is high, linked to strong biological and chemical tractability. Biomarker strategies are tailored to disease specificity. Despite high competition in NRF2 activation, there’s potential for first-in-class...