Fetal Liver Metabolism: TRPV4 Acetylation and mTORC1 Regulation

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This study explores the acetylation of TRPV4 at lysine 608 by the enzyme P300 and its role in regulating mTORC1 activity within the fetal liver. Highlighting the effects of low-glucose prenatal environments, the research uses a TRPV4-K608R mouse model to examine liver development, protein synthesis, and metabolic adaptations under nutrient-limited conditions. Findings underline the critical role of TRPV4 acetylation in fetal health, linking it to postnatal metabolic regulation and growth. The...